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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Genomic convergence ： ウィキペディア英語版 Genomic convergence Genomic convergence is a multifactor approach used in genetic research that combines different kinds of genetic data analysis to identify and prioritize susceptibility genes for a complex disease. == Early Applications == In January 2003, (Michael Hauser ) along with fellow researchers at the (Duke Center for Human Genetics (CHG) ) coined the term “genomic convergence” to describe their endeavor to identify genes affecting the expression of Parkinson disease (PD). Their work successfully combined serial analysis of gene expression (SAGE) with genetic linkage analysis. The authors explain, “While both linkage and expression analyses are powerful on their own, the number of possible genes they present as candidates for PD or any complex disorder remains extremely large”. The convergence of the two methods allowed researchers to decrease the number of possible PD genes to consider for further study. Their success prompted further use of the genomic convergence method at the (CHG ), and in July 2003 (Yi-Ju Li ), ''et al.'' published a paper revealing that glutathione S-transferase omega-1 (GSTO1) modifies the age-at-onset (AAO) of Alzheimer disease (AD) and PD. In May 2004, (Dr. Margaret Pericak-Vance ), currently the director of the (John P. Hussman Institute for Human Genomics ) at the (University of Miami Miller School of Medicine ) and then the director of the (CHG ), articulated the value of the genomic convergence method at a (New York Academy of Sciences (NYAS) ) keynote address entitled "Novel Methods in Genetic Exploration of Neurodegenerative Disease." She stated, "No single method is going to get us where we need to be with these complex traits. It is going to take a combination of methods to dissect the underlying etiology of these disorders". 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Genomic convergence」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.